Bogart’s Legacy maintains an active research program examining unanswered questions in canine health and veterinary medicine. Papers are organized by category and status so researchers, veterinarians, and owners can follow the work as it develops. As manuscripts are completed, they will be submitted to appropriate peer-reviewed veterinary, biomedical, and scientific journals for consideration.
A comprehensive analysis of Bogart’s lymphoma, MDR1 M/M status, CCNU treatment, severe hepatotoxicity, supportive care, clinical decline, and the treatment questions his case leaves unresolved.
In DevelopmentA hypothesis paper examining ABCB1/P-glycoprotein, lymphoma biology, chemotherapy resistance, relapse, and potentially useful adjunctive compounds.
In DevelopmentInvestigates whether complete ABCB1/P-glycoprotein deficiency may affect cortisol transport, HPA-axis regulation, endocrine stress physiology, and recovery — not merely sensitivity to recognized P-gp substrate drugs.
In DevelopmentAn exploratory project examining whether health, longevity, cancer, physiologic stress, reproductive history, environmental exposure, and recovery differ among dogs with varying ABCB1/MDR1 genotypes — drawing on breeder and owner observations to generate hypotheses, not establish causation.
In Development — Research framework & survey design phaseA research-based examination of the gap between veterinary science and its translation into understandable, usable clinical guidance for veterinarians and pet owners. The paper examines communication failures, access to specialist interpretation, shared decision-making, owner dissatisfaction, and what happens when emerging or uncertain science reaches an individual patient. It incorporates published data on veterinarian-client trust, dissatisfaction, information needs, shared decision-making, and failures of communication and understanding in veterinary care.
In Development — Near CompletionAn analysis of the gap between established MDR1 drug-sensitivity guidance and the much less developed clinical guidance surrounding MDR1-associated HPA-axis suppression, relative glucocorticoid insufficiency, physiologic stress, and steroid management. The paper examines what is known, what remains unstudied, and the clinical consequences of having documented physiology without validated decision thresholds, testing protocols, or management guidelines.
In Development — Near CompletionNeuroendocrine Vulnerability Across Physiologic Stress, Reproductive-Hormone Change, and Glucocorticoid Exposure
A hypothesis-driven review examining whether ABCB1/MDR1 deficiency may alter neuroendocrine resilience through HPA-axis suppression, altered central corticosteroid exposure, reproductive/neurosteroid transitions, and changes in seizure threshold. It distinguishes established findings from mechanistic inference and specifically identifies the studies needed to test the proposed relationships.
In DevelopmentReviews current evidence on diagnosis, treatment, prognosis, survival, relapse, and the major gaps still facing canine T-cell lymphoma research.
In QueueA case-history and hypothesis framework exploring reported ancestral exposure, possible offspring effects, liver vulnerability, and lymphoma — without asserting causation.
In DevelopmentEvaluates possible supportive agents for lymphoma, hepatic injury, oxidative stress, inflammation, and treatment tolerance, including MDR1 and drug-interaction risk.
In DevelopmentAn evidence-based look at herbs, supplements, and nutraceuticals in MDR1-deficient dogs through P-glycoprotein transport, drug–supplement interactions, CYP metabolism, Nrf2 signaling, oxidative stress, and hepatic protection — identifying research gaps and hypotheses for supportive-care decisions.
In Development — Near completionA working clinical-support framework, rather than a stand-alone research paper, bringing together supportive-care guidance developed through Bogart’s case. Will be presented in full as the framework develops.
In QueueExamines what dog owners can actually determine about foods marketed for long-term feeding — nutrient composition, organ content, copper and vitamin burdens, manufacturer testing, disclosure practices, AAFCO standards, and the limits of “complete and balanced.”
In Development — Near completionEvaluates rosemary extract, botanical additives, fat composition, protein selection, and other ingredients that may matter for neurologically vulnerable dogs.
In DevelopmentExamines what the evidence actually shows about high dietary protein in healthy, senior, and diseased dogs — protein quantity versus quality, preservation of lean body mass, and whether evidence supports the claim that high protein damages healthy kidneys.
In QueueInvestigates microbial biofilms in food and water bowls, the effect of bowl material and cleaning practices, organisms identified in contaminated bowls, and whether evidence actually links contaminated drinking water to urinary or renal disease, acute kidney injury, sepsis, or death in dogs.
In QueueCurrently a section of the HPA-Axis paper, but may become a standalone hypothesis paper if sufficient evidence emerges concerning estrus-associated seizure patterns.
In DevelopmentInvestigates liver-injury risk, monitoring, protective strategies, treatment interruption, supportive care, and how that risk is disclosed to owners.
In DevelopmentA proposed standards paper covering toxicity monitoring, nutrition, hydration, intervention thresholds, and quality-of-life protection during cancer treatment.
In QueueA proposed paper addressing off-label treatment disclosure, realistic outcomes, alternatives, MDR1-specific considerations, and owner decision authority.
In QueueExamines evidence on the duration of rabies vaccine immunity alongside current legal mandates, with attention to where scientific findings and regulatory policy may differ and what changes might merit consideration.
In DevelopmentReviews maternal antibody protection, the timing and response to early vaccination, and the evidence used to establish subsequent revaccination schedules.
In DevelopmentInvestigates documented adverse events, repeated vaccine exposure and possible differences in individual susceptibility, with the aim of evaluating whether current monitoring and vaccination standards adequately account for risk.
In DevelopmentPapers are organized by primary category, with related areas shown as secondary tags when a project spans more than one field of research.
Each paper also carries a status label showing where the work currently stands: In Development, In Queue, or Completed.
The category structure will continue to be refined as the full body of work is organized, with the goal of maintaining a clear, manageable research library rather than creating too many narrow or overlapping sections.